DNA Alkylation Damage as a Sensor of Nitrosative Stress in Mycobacterium tuberculosis
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چکیده
منابع مشابه
DNA alkylation damage as a sensor of nitrosative stress in Mycobacterium tuberculosis.
One of the cellular consequences of nitrosative stress is alkylation damage to DNA. To assess whether nitrosative stress is registered on the genome of Mycobacterium tuberculosis, mutants lacking an alkylation damage repair and reversal operon were constructed. Although hypersensitive to the genotoxic effects of N-methyl-N'-nitro-N-nitrosoguanidine in vitro, the mutants displayed no phenotype i...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2003
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.71.2.997-1000.2003